Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillator dynamics, together with the interaction of multiple time scales, account for the reported diversity. We confirm our predictions in seizures and tractography data obtained from patients with pharmacologically resistant epilepsy. Our results contribute toward patient-specific seizure modeling.

中文翻译：

---

预测人类局灶性癫痫发作和终止发作的时空多样性。

最近的研究表明，癫痫发作可以通过多种时空模式在大脑区域扩散和终止。特别是，尽管发作的区域通常在单个患者的发作之间是不变的，但是发作期间行进（2-3 Hz）的尖峰和波放电的来源可能随较慢的传播波波前移而移动或保留固定在癫痫发作区。此外，尽管许多局灶性癫痫发作在大脑区域同步终止，但有些发作演变成独特的发作性簇并异步终止。在这里，我们介绍一种基于新的癫痫发作动态神经场模型的统一观点。两种主要机制，在可激发介质中的波传播和振动耦合动力学的并存，加上多个时间尺度的相互作用，说明了所报告的多样性。我们证实了从药理学上具有抗药性的癫痫患者的癫痫发作和体检数据中的预测。我们的结果有助于针对特定患者的癫痫发作建模。