Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca,Journal of Natural Products

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Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-03-13 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00992
Rohitesh Kumar ₁ , Sandra Duffy ₁ , Vicky M. Avery ₁ , Anthony R. Carroll ₁ , Rohan A. Davis ₁

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Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline–serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC₅₀ of 7.7 μM. Microthecaline A represents the first quinoline–serrulatane alkaloid to be isolated from Nature.

中文翻译：

Microthecaline A，一种喹啉Serrulatane生物碱，来自澳大利亚沙漠植物Eremophila microtheca的根

对澳大利亚荒漠植物小叶艾美耳的根进行化学研究后，产生了微茶碱A（1），这是一种新型的喹啉-异硫氰酸烷天然产物。1的结构通过光谱分析确定，并且绝对构型由ECD分配。化合物1对恶性疟原虫（3D7株）表现出中等的抗疟活性，IC ₅₀为7.7μM。微型茶碱A代表第一种从自然界中分离出来的喹啉-异鲁拉塔烷生物碱。

更新日期：2018-03-13

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