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Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-03-13 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00992
Rohitesh Kumar 1 , Sandra Duffy 1 , Vicky M. Avery 1 , Anthony R. Carroll 1 , Rohan A. Davis 1
Affiliation  

Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline–serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline–serrulatane alkaloid to be isolated from Nature.

中文翻译:

Microthecaline A,一种喹啉Serrulatane生物碱,来自澳大利亚沙漠植物Eremophila microtheca的根

对澳大利亚荒漠植物小叶艾美耳的根进行化学研究后,产生了微茶碱A(1),这是一种新型的喹啉-异硫氰酸烷天然产物。1的结构通过光谱分析确定,并且绝对构型由ECD分配。化合物1恶性疟原虫(3D7株)表现出中等的抗疟活性,IC 50为7.7μM。微型茶碱A代表第一种从自然界中分离出来的喹啉-异鲁拉塔烷生物碱。
更新日期:2018-03-13
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