Design and Fabrication of a Hierarchically Structured Scaffold for Tendon‐to‐Bone Repair,Advanced Materials

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Design and Fabrication of a Hierarchically Structured Scaffold for Tendon‐to‐Bone Repair
Advanced Materials ( IF 27.4 ) Pub Date : 2018-03-13 , DOI: 10.1002/adma.201707306
Chunlei Zhu ₁ , Suphannee Pongkitwitoon ₂ , Jichuan Qiu ₁ , Stavros Thomopoulos _{2,

3} , Younan Xia _{1,

4}

Affiliation

A hierarchically structured scaffold is designed and fabricated for facilitating tendon‐to‐bone repair. The scaffold is composed of three regions with distinct functions: (i) an array of channels to guide the in‐growth of cells and aligned deposition of collagen fibers, as well as integration of the scaffold with the tendon side, (ii) a region with a gradient in mineral composition to facilitate stress transfer between tendon and bone, and (iii) a mineralized inverse opal region to promote the integration of the scaffold with the underlying bone. Cell culture experiments confirm that adipose‐derived stromal cells are able to infiltrate and proliferate through the entire thickness of the scaffold without compromised cell viability. The seeded stem cells exhibit directed differentiation into tenocytes and osteoblasts along the mineral gradient as a response to the gradient in Young's modulus. This novel scaffold holds great promise to promote the formation of a functional tendon‐to‐bone attachment by offering a structurally and compositionally appropriate microenvironment for healing.

中文翻译：

用于腱骨修复的分层结构支架的设计和制造

设计和制造了分层结构的支架，以促进肌腱到骨骼的修复。该支架由具有不同功能的三个区域组成：（i）引导细胞向内生长和胶原纤维对齐沉积的通道阵列，以及支架与肌腱侧的整合，（ii）一个区域具有矿物成分梯度，以促进肌腱和骨骼之间的应力传递，以及（iii）矿化反蛋白石区域，以促进支架与下方骨骼的整合。细胞培养实验证实，脂肪来源的基质细胞能够渗透并增殖到支架的整个厚度，而不会损害细胞活力。作为对杨氏模量梯度的响应，接种的干细胞沿着矿物质梯度定向分化为肌腱细胞和成骨细胞。这种新颖的支架有望通过提供结构和成分合适的愈合微环境来促进功能性肌腱与骨骼附着的形成。

更新日期：2018-03-13

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