Diastereoselective Construction of Indole-Bridged Chroman Spirooxindoles through a TfOH-Catalyzed Michael Addition-Inspired Cascade Reaction,The Journal of Organic Chemistry

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Diastereoselective Construction of Indole-Bridged Chroman Spirooxindoles through a TfOH-Catalyzed Michael Addition-Inspired Cascade Reaction
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-03-13 00:00:00 , DOI: 10.1021/acs.joc.8b00035
Jiaomei Guo ₁ , Xuguan Bai ₁ , Qilin Wang ₁ , Zhanwei Bu ₁

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The first highly diastereoselective Michael addition/condensation/Friedel–Crafts alkylation cascade reaction of 3-indolyl-substituted oxindoles with ortho-hydroxychalcones was established, which afforded a wide range of polycyclic indole-bridged chroman spirooxindoles with novel and complex scaffolds in moderate to excellent yields.

中文翻译：

通过TfOH催化的迈克尔加成反应的级联反应，非对映选择性地构建吲哚桥环螺氧杂吲哚。

建立了第一个3-位吲哚基取代的吲哚与邻羟基查尔酮的高非对映选择性迈克尔加成/缩合/弗里德-克来夫特烷基化级联反应，该反应提供了多种由多环吲哚桥连的苯并二氢并吡喃并恶心螺酮制成，具有中等至优异的新型和复杂骨架。产量。

更新日期：2018-03-13

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