Drugs are rarely defined by a single act in a disease treatment but often elicit a cure with few side effects. In this respect, recent clinical analyses of treatment with antipsychotic drugs such as chlorpromazine (CPZ) show that high dose of CPZ leads to severe extrapyramidal side effects. To address the incidence of these side effects, CPZ was incorporated into montmorillonite (MMt) clay in order to gradually release it over a prolonged period. As a consequence of a lamellar structure and biocompatibility, MMt is mainly used as nanocarrier for the controlled release of several chemical drugs. XRD, FT-IR, DSC-TGA and SEM techniques were used to characterize the structure of the prepared formulation, all confirming the successful intercalation of CPZ into MMt interlayer spaces. The potential application was verified through release of CPZ from CPZ/MMt formulation. The drug release profile indicated that the release of the intercalated CPZ was slower than the release of the CPZ lonely (pure). The presence of the MMt clay in CPZ/MMt capsule beads reduced the release rate and upheld the sustained release of the model drug for a longer period. To elucidate the release mechanism of CPZ from CPZ/MMt formulation, the release data were subjected to release kinetic. Thus, the results suggested the feasibility of the use of MMt clay materials for controlled manner of drugs, and thereby, a sustained release is favorable and side effects reduced.

在疾病治疗中，药物很少通过单一作用来定义，但常常可以治愈而几乎没有副作用。在这方面，最近用抗精神病药如氯丙嗪（CPZ）治疗的临床分析表明，高剂量的CPZ会导致严重的锥体束外副作用。为了解决这些副作用的发生，CPZ被掺入了蒙脱石（MMt）粘土中，以便在长时间内逐渐释放出来。由于具有层状结构和生物相容性，因此MMt主要用作控制多种化学药物释放的纳米载体。XRD，FT-IR，DSC-TGA和SEM技术用于表征所制备制剂的结构，所有这些都证实了CPZ已成功插入MMt层间空间。通过从CPZ / MMt配方中释放CPZ验证了潜在的应用。药物释放曲线表明，插层CPZ的释放比CPZ孤独（纯）的释放要慢。CPZ / MMt胶囊珠粒中MMt粘土的存在降低了释放速率，并维持了模型药物的持续释放更长的时间。为了阐明CPZ从CPZ / MMt配方中的释放机理，对释放数据进行了释放动力学。因此，结果表明使用MMt粘土材料控制药物的可行性，因此，持续释放是有利的并且副作用减少。CPZ / MMt胶囊珠粒中MMt粘土的存在降低了释放速率，并维持了模型药物的持续释放更长的时间。为了阐明CPZ从CPZ / MMt配方中的释放机理，对释放数据进行了释放动力学。因此，结果表明使用MMt粘土材料控制药物的可行性，因此，持续释放是有利的并且副作用减少。CPZ / MMt胶囊珠粒中MMt粘土的存在降低了释放速率，并维持了模型药物的持续释放更长的时间。为了阐明CPZ从CPZ / MMt配方中的释放机理，对释放数据进行了释放动力学。因此，结果表明使用MMt粘土材料控制药物的可行性，因此，持续释放是有利的并且副作用减少。