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High Accuracy Ion Mobility Spectrometry for Instrument Calibration
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-03-13 00:00:00 , DOI: 10.1021/acs.analchem.7b04987
Brian C. Hauck 1 , William F. Siems 1 , Charles S. Harden 2 , Vincent M. McHugh 3 , Herbert H. Hill 1
Affiliation  

Ion mobility spectrometry (IMS) is widely used to characterize compounds of interest (COIs) based on their reduced mobility (K0) values. In an attempt to increase the accuracy and agreement of studies, the most recommended method has been to use a reference compound with a known K0 value to calibrate the instrument and calculate COI K0 values from normalized spectra. Researchers are limited by the accuracy of previous K0 value reference measurements on which to base their calibrations. Any inaccuracy in these reference K0 values, typically ±2%, will propagate through to the calculated K0 value of the COI. For this reason, there is a need to standardize reference K0 values with improved accuracy. Through improvement of the accuracy of reference measurements, a lower degree of error will propagate through new K0 value calculations. The K0 values of the ammonium reactant ion, the potential reference standard dimethyl methylphosphonate (DMMP), and three explosive COIs were characterized at multiple drift gas temperatures, drift gas water contents, and electric field strengths on an accurate ion mobility spectrometry instrument. K0 values reported here are known to ±0.1% as a result of reducing the error of all instrumental parameters.

中文翻译:

高精度离子迁移谱仪,用于仪器校准

离子迁移谱(IMS)被广泛用于基于目标化合物(CO 0)降低的迁移率(K 0)值来表征目标化合物。为了提高研究的准确性和一致性,最推荐的方法是使用具有已知K 0值的参考化合物校准仪器并从归一化光谱计算COI K 0值。研究人员受到以前基于K 0值参考测量的准确性的限制,这些校准是基于它们进行校准的。这些参考K 0值中的任何误差(通常为±2%)都会传播到计算出的K 0中COI的值。因此,需要以更高的精度对参考K 0值进行标准化。通过提高参考测量的精度,较低的误差程度将通过新的K 0值计算而传播。使用精确的离子迁移谱仪,在多种漂移气体温度,漂移气体水含量和电场强度下,对铵反应离子,潜在的参考标准甲基二甲基甲基膦酸二甲酯(DMMP)和三种爆炸性COI的K 0值进行了表征。由于减少了所有仪器参数的误差,因此此处报告的K 0值已知为±0.1%。
更新日期:2018-03-13
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