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Gold nanorods for in-drop colorimetric determination of thiomersal after photochemical decomposition
Microchimica Acta ( IF 5.3 ) Pub Date : 2018-03-13 , DOI: 10.1007/s00604-018-2760-3
Manuel Martín-Alonso , Francisco Pena-Pereira , Isela Lavilla , Carlos Bendicho

AbstractThis work reports on the implementation of gold nanorods (AuNRs) in headspace solvent microextraction for colorimetric determination of volatile analyte derivatives in a single drop. The exposure of AuNRs to both H2Se and elemental mercury (Hg0) results in a shift of the longitudinal plasmonic band, unlike a number of volatiles. Accordingly, a method is reported for the determination of Hg0 with potential applicability to the determination of thiomersal (sodium ethylmercurithiosalicylate). It is based on the photochemical decomposition of thiomersal into Hg(II) and subsequent exposure of AuNRs-containing microdrop to in situ generated Hg0. Colorimetric analysis of the enriched drop was carried out without dilution by means of a cuvetteless microvolume UV-vis spectrometer. Under optimal conditions, the limit of detection was 0.5 ng mL−1 (as Hg). The repeatability, expressed as relative standard deviation, was 8.4% (for n = 10). AuNRs exposed to increasing concentrations of the analyte were characterized by means of transmission electron microscopy and UV-vis spectrophotometry to ascertain the mechanism of detection. The method was finally applied to the determination of thiomersal in various pharmaceutical samples and showed quantitative recoveries. Graphical abstractSchematic illustration of a miniaturized colorimetric method based on the use of a microdrop of gold nanorods (AuNRs) for thiomersal determination in pharmaceuticals. It is based on the photochemical decomposition of thiomersal and subsequent Hg0 generation with in-drop amalgamation.

中文翻译:

用于光化学分解后硫柳汞滴内比色测定的金纳米棒

摘要这项工作报告了金纳米棒 (AuNRs) 在顶空溶剂微萃取中的实施,用于比色测定单滴挥发性分析物衍生物。与许多挥发物不同,AuNR 暴露于 H2Se 和元素汞 (Hg0) 会导致纵向等离子体带的移动。因此,报告了一种测定 Hg0 的方法,该方法可能适用于测定硫柳汞(乙基汞硫代水杨酸钠)。它基于硫柳汞光化学分解成 Hg(II),随后将含 AuNRs 的微滴暴露于原位生成的 Hg0。富集液滴的比色分析是在没有稀释的情况下通过无比色皿微体积紫外-可见光谱仪进行的。在最佳条件下,检测限为0。5 ng mL−1(以 Hg 计)。以相对标准偏差表示的重复性为 8.4%(对于 n = 10)。通过透射电子显微镜和紫外可见分光光度法对暴露于浓度增加的分析物的 AuNR 进行表征,以确定检测机制。该方法最终应用于各种药物样品中硫柳汞的测定,并显示出定量回收率。图形摘要基于使用微滴金纳米棒 (AuNRs) 测定药物中硫柳汞的小型化比色方法的示意图。它基于硫柳汞的光化学分解和随后的汞齐化产生的汞。通过透射电子显微镜和紫外可见分光光度法对暴露于浓度增加的分析物的 AuNR 进行表征,以确定检测机制。该方法最终应用于各种药物样品中硫柳汞的测定,并显示出定量回收率。图形摘要基于使用微滴金纳米棒 (AuNRs) 测定药物中硫柳汞的小型化比色方法的示意图。它基于硫柳汞的光化学分解和随后的汞齐化产生的汞。通过透射电子显微镜和紫外可见分光光度法对暴露于浓度增加的分析物的 AuNR 进行表征,以确定检测机制。该方法最终应用于各种药物样品中硫柳汞的测定,并显示出定量回收率。图形摘要基于使用微滴金纳米棒 (AuNRs) 测定药物中硫柳汞的小型化比色方法的示意图。它基于硫柳汞的光化学分解和随后的汞齐化产生的汞。该方法最终应用于各种药物样品中硫柳汞的测定,并显示出定量回收率。图形摘要基于使用微滴金纳米棒 (AuNRs) 测定药物中硫柳汞的小型化比色方法的示意图。它基于硫柳汞的光化学分解和随后的汞齐化产生的汞。该方法最终应用于各种药物样品中硫柳汞的测定,并显示出定量回收率。图形摘要基于使用微滴金纳米棒 (AuNRs) 测定药物中硫柳汞的小型化比色方法的示意图。它基于硫柳汞的光化学分解和随后的汞齐化产生的汞。
更新日期:2018-03-13
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