Photo‐biocatalytic One‐Pot Cascades for the Enantioselective Synthesis of 1,3‐Mercaptoalkanol Volatile Sulfur Compounds,Angewandte Chemie International Edition

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Photo‐biocatalytic One‐Pot Cascades for the Enantioselective Synthesis of 1,3‐Mercaptoalkanol Volatile Sulfur Compounds
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-04-14 , DOI: 10.1002/anie.201802135
Kate Lauder ₁ , Anita Toscani ₁ , Yuyin Qi ₂ , Jesmine Lim ₂ , Simon J. Charnock ₂ , Krupa Korah ₁ , Daniele Castagnolo ₁

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The synthesis of enantiomerically pure 1,3‐mercaptoalkanol volatile sulfur compounds through a one‐pot photo‐biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one‐pot cascade reaction combining photocatalytic thio‐Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1,3‐mercaptoalkanols in high yields with excellent enantioselectivity.

中文翻译：

对映选择性合成1,3-巯基链烷醇挥发性硫化合物的光生物催化一锅级联反应

描述了通过单锅光生物催化级联反应合成对映体纯的1,3-巯基链烷醇挥发性硫化合物。发现了两种具有相反对映选择性的新型KRED生物催化剂，并证明它们在多种底物上均有效。在水介质中将光催化硫代迈克尔加成反应与生物催化酮还原反应相结合的单锅级联反应为高对映体纯的1,3-巯基链烷醇的生产提供了绿色且可持续的方法，并具有出色的对映选择性。

更新日期：2018-04-14

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