Magnetophoretic induced convective capture of highly diffusive superparamagnetic nanoparticles†,Soft Matter

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Magnetophoretic induced convective capture of highly diffusive superparamagnetic nanoparticles†
Soft Matter ( IF 2.9 ) Pub Date : 2018-03-13 00:00:00 , DOI: 10.1039/c7sm02324c
M. Fratzl _{1,

2,

3,

4,

5} , S. Delshadi _{1,

2,

3,

4,

5} , T. Devillers _{1,

2,

3,

6,

7} , F. Bruckert _{1,

2,

3,

7,

8} , O. Cugat _{1,

2,

3,

6,

7} , N. M. Dempsey _{1,

2,

3,

6,

7} , G. Blaire _{1,

2,

3,

4,

5}

Affiliation

Micro-magnets producing magnetic field gradients as high as 10⁶ T m⁻¹ have been used to efficiently trap nanoparticles with a magnetic core of just 12 nm in diameter. Particle capture efficiency increases with increasing particle concentration. Comparison of measured capture kinetics with numerical modelling reveals that a threshold concentration exists below which capture is diffusion-driven and above which it is convectively-driven. This comparison also shows that two-way fluid–particle coupling is responsible for the formation of convective cells, the size of which is governed by the height of the droplet. Our results indicate that for a suspension with a nanoparticle concentration suitable for bioassays (around 0.25 mg ml⁻¹), all particles can be captured in less than 10 minutes. Since nanoparticles have a significantly higher surface-to-volume ratio than the more widely used microparticles, their efficient capture should contribute to the development of next generation digital microfluidic lab-on-chip immunoassays.

中文翻译：

磁致对流捕获高度扩散的超顺磁性纳米粒子†

产生高达10 ⁶ T m ^-1的磁场梯度的微磁体已用于有效捕获直径仅为12 nm的磁芯的纳米颗粒。颗粒捕获效率随颗粒浓度的增加而增加。将测得的捕获动力学与数值模型进行比较表明，存在阈值浓度，在该阈值浓度以下，捕获是扩散驱动的，在该阈值以上是对流驱动的。这种比较还表明，双向流固耦合是对流细胞形成的原因，对流细胞的大小由液滴的高度决定。我们的结果表明，对于具有适用于生物测定的纳米颗粒浓度的悬浮液（约0.25 mg ml ^-1），可以在不到10分钟的时间内捕获所有颗粒。由于纳米颗粒的表面体积比明显高于使用更广泛的微粒，因此它们的有效捕获应有助于下一代数字微流控芯片实验室免疫分析技术的发展。

更新日期：2018-03-13

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