Acquired traumatic brain injury (TBI) is frequently accompanied by persistent cognitive symptoms, including executive function disruptions and memory deficits. The Morris Water Maze (MWM) is the most widely-employed laboratory behavioral test for assessing cognitive deficits in rodents after experimental TBI. Numerous protocols exist for performing the test, which has shown great robustness in detecting learning and memory deficits in rodents after infliction of TBI. We review applications of the MWM for the study of cognitive deficits following TBI in pre-clinical studies, describing multiple ways in which the test can be employed to examine specific aspects of learning and memory. Emphasis is placed on dependent measures that are available and important controls that must be considered in the context of TBI. Finally, caution is given regarding interpretation of deficits as being indicative of dysfunction of a single brain region (hippocampus), as experimental models of TBI most often result in more diffuse damage that disrupts multiple neural pathways and larger functional networks that participate in complex behaviors required in MWM performance.

获得性外伤性脑损伤（TBI）经常伴有持续的认知症状，包括执行功能中断和记忆力减退。莫里斯水迷宫（MWM）是应用最广泛的实验室行为测试，用于评估实验性TBI后啮齿动物的认知缺陷。存在用于执行该测试的许多协议，这些协议在检测TBI造成的啮齿类动物的学习和记忆缺陷方面表现出了强大的鲁棒性。我们在临床前研究中回顾了MWM在TBI之后的认知功能障碍研究中的应用，描述了可以使用该测试来检查学习和记忆的特定方面的多种方式。重点放在可用的依赖措施以及在TBI范围内必须考虑的重要控制措施。最后，