Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCRβ sequences .

中文翻译：

---

与病症相关的公共抗原受体序列的鉴定方法


高变免疫球蛋白受体（TCR 和 BCR）的多种功能可识别适应性免疫系统中的抗原。免疫球蛋白受体库测序方法的发展使得对抗原受体序列进行全库疾病关联研究成为可能。我们开发了一个统计框架，用于将受体与一小部分患者的疾病相关联，而不需要对照组。我们的方法成功识别了先前验证的巨细胞病毒和一型糖尿病反应性 TCRβ 序列。