Water‐Mediated One‐Pot Three‐Component Reaction to Bifunctionalized Thiadiazoloquinazolinone‐coumarin Hybrids: A Green Approach,ChemistrySelect

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Water‐Mediated One‐Pot Three‐Component Reaction to Bifunctionalized Thiadiazoloquinazolinone‐coumarin Hybrids: A Green Approach
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-03-13 , DOI: 10.1002/slct.201702908
Preeti Wadhwa ₁ , Anupreet Kharbanda ₁ , Sourav Bagchi ₁ , Anuj Sharma ₁

Affiliation

A facile, eco‐friendly protocol has been developed for synthesis of novel bifunctional coumarin‐thiadiazoloquinazolinone containing heterocycles via one pot, three component reaction of 5‐aryl‐1,3,4‐thiadiazol‐2‐amines, 1,3‐dicarbonyls and 2‐oxo‐2H‐chromene‐3‐carbaldehyde under microwave irradiation in water. Characteristics of the method include the use of environmentally benign solvent and catalyst, mild reaction conditions, moderate to high yields of products and the applicability of microwave irradiation as a source of energy.

中文翻译：

双官能化的噻二唑并喹唑啉酮-香豆素杂合体的水介导的单罐三组分反应：一种绿色方法

已开发出一种简便，环保的方案，用于通过一锅，5-芳基-1,3,4-噻二唑-2-胺，1,3-二羰基化合物和三芳基化合物的三组分反应合成含有杂环的新型双功能香豆素-噻二唑并喹唑啉酮。水中微波照射下的2-氧代2 H 2色烯3甲醛。该方法的特征包括使用环境友好的溶剂和催化剂，温和的反应条件，中等至高产率的产物以及微波辐射作为能源的适用性。

更新日期：2018-03-13

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