In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3'-to-5' mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery.

中文翻译：

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靶向AML中的mRNA降解。

在本期《癌细胞》中，Yamauchi等人。确定急性髓性白血病（AML）对DCPS的依赖性，它催化3'至5'mRNA衰变的最后一步，并涉及RNA代谢的许多方面。DCPS可通过临床抑制剂靶向，从而强调了这一发现的翻译重要性。