Disruptions in the antagonistic balance between the chromatin-modifying Polycomb and Trithorax group proteins drive many malignancies. In this issue of Cancer Cell, Banito et al. describe how the SS18-SSX oncogenic fusion protein in synovial sarcoma directly co-opts these complexes to drive gene dysregulation and sustain the transformed state.

中文翻译：

---

滑膜肉瘤的非规范性多梳依赖性。

染色质修饰的Polycomb和Trithorax组蛋白之间拮抗平衡的破坏导致了许多恶性肿瘤。在此期的《癌细胞》中，Banito等人。描述滑膜肉瘤中的SS18-SSX致癌融合蛋白如何直接选择这些复合物来驱动基因失调并维持转化状态。