当前位置：
X-MOL 学术
›
Mol. Nutr. Food Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The Role of Non‐Coding RNAs and Isothiocyanates in Cancer
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-05-28 , DOI: 10.1002/mnfr.201700913 Samantha L Martin 1 , Kendra J Royston 1 , Trygve O Tollefsbol 1, 2, 3, 4, 5
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-05-28 , DOI: 10.1002/mnfr.201700913 Samantha L Martin 1 , Kendra J Royston 1 , Trygve O Tollefsbol 1, 2, 3, 4, 5
Affiliation
|
Cancer is the second leading cause of mortalities in the United States, only exceeded by heart disease. Current cancer treatments include chemotherapy, surgery, and/or radiation. Due to the often harsh effects of current cancer therapies, investigators are focusing their efforts on cancer prevention mediated by dietary phytochemicals. Since the discovery that cancer can be initiated by and progressed through both genetic and epigenetic pathways, there has been a significant surge in studies on epigenetic effects mediated by nutritive compounds. Isothiocyanates, naturally occurring molecules found in cruciferous vegetables, have been documented to exhibit many anticarcinogenic activities. Although isothiocyanates have been extensively documented as key players in epigenetic processes such as DNA methylation and histone modifications, their effects on non‐coding RNAs is understudied. Non‐coding RNAs are molecules that target mRNA production and repress protein translation and are known to be dysregulated in various human malignancies. Studies have used non‐coding RNAs as novel targets for exploration in cancer therapy. This review focuses on the exploration of isothiocyanates and their effect on non‐coding RNAs in cancer prevention and therapy.
中文翻译：
非编码 RNA 和异硫氰酸盐在癌症中的作用
癌症是美国第二大死亡原因，仅次于心脏病。目前的癌症治疗包括化疗、手术和/或放疗。由于当前的癌症疗法常常产生严重影响，研究人员将重点放在通过膳食植物化学物质介导的癌症预防上。自从发现癌症可以通过遗传和表观遗传途径引发和发展以来，对营养化合物介导的表观遗传效应的研究急剧增加。异硫氰酸盐是十字花科蔬菜中天然存在的分子，已被证明具有许多抗癌活性。尽管异硫氰酸盐已被广泛记录为 DNA 甲基化和组蛋白修饰等表观遗传过程的关键参与者，但其对非编码 RNA 的影响尚未得到充分研究。非编码 RNA 是靶向 mRNA 生成并抑制蛋白质翻译的分子，已知在各种人类恶性肿瘤中失调。研究已使用非编码 RNA 作为探索癌症治疗的新靶标。本综述重点探讨异硫氰酸盐及其在癌症预防和治疗中对非编码 RNA 的影响。
更新日期：2018-05-28
中文翻译：
非编码 RNA 和异硫氰酸盐在癌症中的作用
癌症是美国第二大死亡原因，仅次于心脏病。目前的癌症治疗包括化疗、手术和/或放疗。由于当前的癌症疗法常常产生严重影响，研究人员将重点放在通过膳食植物化学物质介导的癌症预防上。自从发现癌症可以通过遗传和表观遗传途径引发和发展以来，对营养化合物介导的表观遗传效应的研究急剧增加。异硫氰酸盐是十字花科蔬菜中天然存在的分子，已被证明具有许多抗癌活性。尽管异硫氰酸盐已被广泛记录为 DNA 甲基化和组蛋白修饰等表观遗传过程的关键参与者，但其对非编码 RNA 的影响尚未得到充分研究。非编码 RNA 是靶向 mRNA 生成并抑制蛋白质翻译的分子，已知在各种人类恶性肿瘤中失调。研究已使用非编码 RNA 作为探索癌症治疗的新靶标。本综述重点探讨异硫氰酸盐及其在癌症预防和治疗中对非编码 RNA 的影响。
京公网安备 11010802027423号