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Pharmacognostic and pharmacological evaluation of Eulaliopsis binata plant extracts by measuring in vitro/in vivo safety profile and anti-microbial potential†
Toxicology Research ( IF 2.2 ) Pub Date : 2018-03-12 00:00:00 , DOI: 10.1039/c8tx00017d Vinod Kumar 1, 2, 3, 4 , Arun K. Sharma 2, 3, 4, 5 , Satyendra K. Rajput 2, 3, 4, 5 , Mahesh Pal 4, 6, 7, 8 , Neerupma Dhiman 1, 2, 3, 4
Toxicology Research ( IF 2.2 ) Pub Date : 2018-03-12 00:00:00 , DOI: 10.1039/c8tx00017d Vinod Kumar 1, 2, 3, 4 , Arun K. Sharma 2, 3, 4, 5 , Satyendra K. Rajput 2, 3, 4, 5 , Mahesh Pal 4, 6, 7, 8 , Neerupma Dhiman 1, 2, 3, 4
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The present investigation emphasizes the pharmacognostic and phytochemical screening of Eulaliopsis binata and further evaluates the extracts of this plant for toxicological profile and anti-bacterial potential based on in vivo/in vitro assays. Microscopy, powder characteristics of the leaf material, and physicochemical and phytochemical screening were assessed for pharmacognostic evaluation. Dry leaves of Eulaliopsis binata were extracted using different solvents (methanol, ethyl acetate, and hexane), and the extracts obtained were further investigated for in vitro/in vivo toxicological study. Moreover, acute toxicity was assessed by evaluating the anti-oxidant defense system and anatomical damage in vital organs. In addition, anti-bacterial activity of all the extracts was assessed by the Kirby-Bauer method. Physicochemical and microscopic observations showed the unique identification mark for leaf powder and leaf transverse section. Phytochemical investigation evidenced the presence of flavonoids and phenolic contents in the methanolic extract. All extracts were found to be hemocompatible and exhibited no induction of behavioral alteration and no alteration in the anti-oxidant potential and anatomical structure of the vital organs. On the other hand, the methanolic extract showed a significant upsurge in the reduced glutathione level, whereas all extracts showed significant anti-bacterial potential in a dose-dependent manner. Eulaliopsis binata has inimitable pharmacognostical characteristics, good safety profile and significant anti-oxidant and anti-bacterial potential that show immense possibility for its further investigation for pharmacological use.
中文翻译：
生药和的药理评价龙须草通过测量植物提取物在体外/体内的安全性和抗微生物潜力†
本研究着重于Eulaliopsis binata的药理学和植物化学筛选，并基于体内/体外试验进一步评估了该植物提取物的毒理学特征和抗菌潜能。显微镜检查，叶片材料的粉末特性以及理化和植物化学筛选用于药理学评估。用不同的溶剂（甲醇，乙酸乙酯和己烷）提取Eulaliopsis binata的干叶，然后对所得提取物进行体外/体内研究。毒理学研究。此外，通过评估抗氧化防御系统和重要器官的解剖学损伤来评估急性毒性。另外，通过Kirby-Bauer方法评估了所有提取物的抗菌活性。理化和显微镜观察显示出叶片粉末和叶片横断面的独特识别标记。植物化学研究表明，甲醇提取物中存在类黄酮和酚类成分。发现所有提取物都具有血液相容性，并且没有表现出行为改变的诱导，也没有表现出重要器官的抗氧化电位和解剖结构的改变。另一方面，甲醇提取物在降低的谷胱甘肽水平上显示出明显的上升趋势，ula草具有独特的药理学特征，良好的安全性和显着的抗氧化和抗菌潜力，显示出进一步研究其药理用途的巨大可能性。
更新日期：2018-03-12
中文翻译：
生药和的药理评价龙须草通过测量植物提取物在体外/体内的安全性和抗微生物潜力†
本研究着重于Eulaliopsis binata的药理学和植物化学筛选，并基于体内/体外试验进一步评估了该植物提取物的毒理学特征和抗菌潜能。显微镜检查，叶片材料的粉末特性以及理化和植物化学筛选用于药理学评估。用不同的溶剂（甲醇，乙酸乙酯和己烷）提取Eulaliopsis binata的干叶，然后对所得提取物进行体外/体内研究。毒理学研究。此外，通过评估抗氧化防御系统和重要器官的解剖学损伤来评估急性毒性。另外，通过Kirby-Bauer方法评估了所有提取物的抗菌活性。理化和显微镜观察显示出叶片粉末和叶片横断面的独特识别标记。植物化学研究表明，甲醇提取物中存在类黄酮和酚类成分。发现所有提取物都具有血液相容性，并且没有表现出行为改变的诱导，也没有表现出重要器官的抗氧化电位和解剖结构的改变。另一方面，甲醇提取物在降低的谷胱甘肽水平上显示出明显的上升趋势，ula草具有独特的药理学特征，良好的安全性和显着的抗氧化和抗菌潜力，显示出进一步研究其药理用途的巨大可能性。
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