Multistimuli Responsive Supramolecular Polymeric Nanoparticles Formed by Calixpyridinium and Chondroitin 4‐Sulfate,ChemistrySelect

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Multistimuli Responsive Supramolecular Polymeric Nanoparticles Formed by Calixpyridinium and Chondroitin 4‐Sulfate
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-03-12 , DOI: 10.1002/slct.201800570
Kui Wang ₁ , Xiao-Wei Ren ₁ , Jian-Hua Cui ₁ , Jia-Shuang Guo ₁ , Si-Yang Xing ₁ , Hong-Xi Dou ₁ , Meng-Meng Wang ₁

Affiliation

We have successfully constructed multistimuli responsive supramolecular polymeric nanoparticles based on the complexation of calixpyridinium with polyanionic chondroitin 4‐sulfate. The nanoparticles are disassembled upon increasing pH from 6 to 9, while a pH‐responsive morphological conversion from spherical nanoparticles to nanorods is observed upon decreasing pH from 6 to 2. Adding a competitive guest can also disrupt the assembly, representing the host–guest inclusion response. Interestingly, an unexpected hyaluronidase‐responsive morphological conversion from spherical nanoparticles to wire‐like suprastructures rather than disassembly is also observed, as a result of the hyaluronidase‐induced cleavage of chondroitin 4‐sulfate. The multistimuli responsive morphological conversion property with various dimensions, along with the facile preparation, will make this supramolecular polymeric assembly approach well‐suitable for a variety of important material applications.

中文翻译：

杯盖吡啶鎓和硫酸软骨素形成的多刺激响应性超分子聚合物纳米颗粒

我们已经基于杯盖吡啶鎓与聚阴离子软骨素4-硫酸盐的络合成功构建了多刺激响应性超分子聚合物纳米颗粒。当pH从6增加到9时，纳米颗粒被分解，而pH从6下降到2时，观察到从球形纳米颗粒到纳米棒的pH响应形态转换。添加竞争性客体也会破坏组装，代表了宿主-客体的包容性回复。有趣的是，由于透明质酸酶诱导的硫酸软骨素4-硫酸盐的裂解，还观察到了从球形纳米颗粒到丝状超结构的意外的透明质酸酶响应形态转变，而不是分解。具有多种尺寸的多刺激响应形态转换特性，

更新日期：2018-03-12

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