Development of Acridine‐Derived “Turn On” Al3+ Fluorescent Sensors and Their Imaging in Living Cells,ChemistrySelect

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Development of Acridine‐Derived “Turn On” Al3+ Fluorescent Sensors and Their Imaging in Living Cells
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-03-12 , DOI: 10.1002/slct.201800158
Chaoyu Wang _{1,

2} , Jiaxin Fu _{1,

2} , Kun Yao _{1,

2} , Yongxin Chang _{1,

2} , Li Yang ₂ , Kuoxi Xu _{1,

2}

Affiliation

Two novel highly selective fluorescent sensors L‐1 and L‐2 for the determination of Al³⁺ ion were synthesized and characterized. The sensors acridine‐4,5‐diylbismethyl(bis(oxy))bis(2,1‐phenylene))bis‐(methylene))bis(azanediyl))bis(3‐phenylpropan‐1‐ol) (L‐1) and 2,2′‐acridine‐4,5‐diylbis(methylene(bis(oxy))bis(2,1‐phenylene))bis‐(methylene))bis(azanediyl))bis(propan‐1‐ol) (L‐2) showed “turn on” fluorescence response in the presence of Al³⁺ ion in DMSO/tris‐HCl (1:1, v:v, pH=7.2) buffer solution. Other cations viz. Li⁺, Na⁺, K⁺, Mg²⁺, Ca²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cd²⁺, Cu²⁺, Zn²⁺, Mn²⁺, Ba²⁺, Pb²⁺, Hg²⁺, Fe³⁺ and Eu³⁺ ions showed no appreciable change in fluorescence spectrum. The detection limits of L‐1 and L‐2 for Al³⁺ ion were at the parts per billion level. In addition, possible utilization of sensors as bio‐imaging fluorescent sensors to detect Al³⁺ in human cervical HeLa cells was also investigated by confocal fluorescence microscopy.

中文翻译：

A啶衍生的“开启” Al3 +荧光传感器的开发及其在活细胞中的成像

合成并表征了两种用于测定Al ³⁺离子的新型高选择性荧光传感器L-1和L-2。传感器a啶-4,5-二基双甲基（双（氧基））双（2,1-亚苯基））双-（亚甲基））双（氮杂二基））双（3-苯基丙烷-1-醇）（L-1）和2,2'-r啶-4,5-二基双（亚甲基（双（氧基））双（2,1-亚苯基））双-（亚甲基））双（氮杂二基）双（丙烷-1-醇）（L-2）在DMSO / tris-HCl（1：1，v：v，pH = 7.2）缓冲溶液中存在Al ³⁺离子时显示“开启”荧光响应。其他阳离子。Li ⁺，Na ⁺，K ⁺，Mg 2 ⁺，Ca ²⁺，铁²⁺，Co 2 ⁺，Ni 2 ⁺，Cd 2 ⁺，Cu 2 ⁺，Zn 2 ⁺，Mn 2 ⁺，Ba 2 ⁺，Pb 2 ⁺，Hg 2 ⁺，Fe ³⁺和Eu ³⁺离子没有明显的变化荧光光谱的变化。Al ³⁺离子的L-1和L-2的检出限为十亿分之几的水平。此外，还通过共聚焦荧光显微镜研究了将传感器用作生物成像荧光传感器来检测人宫颈HeLa细胞中Al ^3+的可能性。

更新日期：2018-03-12

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