A general route towards 3‐O‐alkylated DOPA derivatives has been developed. The regioselectivity of the synthesis was controlled by the number of base equivalents in the first alkylation step. In this way a photo‐caged DOPA was prepared that can readily be incorporated into recombinant protein sequences, thus enabling biosynthetic production of light‐activatable bioadhesives.

中文翻译：

---

通过3,4-二羟基苯甲醛的选择性烷基化合成光笼DOPA衍生物

已经开发了一种制备3-O-烷基化DOPA衍生物的一般方法。合成的区域选择性由第一烷基化步骤中碱当量的数量控制。这样，制备了光笼装的DOPA，可以将其轻松地掺入重组蛋白序列中，从而能够生物合成生产可光活化的生物粘合剂。