Nanoparticles for photothermal therapy: Real‐time temperature monitoring is critical to reduce the nonspecific damage during photothermal therapy (PTT); however, PTT agents that can emit temperature‐related signals are rare and limited to few inorganic nanoparticles. We herein synthesize a semiconducting polymer nanococktail (SPN_CT) that can not only convert photo‐energy to heat but also emit temperature‐correlated luminescence after cessation of light excitation. Such an afterglow luminescence of the SPN_CT detects tumors more sensitively than fluorescence as a result of the elimination of tissue autofluorescence, while its temperature‐dependent nature allows tumor temperature to be optically monitored under near‐infrared (NIR) laser irradiation. Thus, SPN_CT represents the first organic optical nanosystem that enables optical‐imaging guided PTT without real‐time light excitation.

中文翻译：

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用于成像引导光热疗法的半导体聚合物纳米鸡尾酒的温度相关余辉

用于光热疗法的纳米粒子：实时温度监测对于减少光热疗法（PTT）期间的非特异性损伤至关重要；但是，能够发出与温度有关的信号的PTT试剂很少，并且仅限于极少数的无机纳米粒子。我们在此合成了一种半导体聚合物纳米鸡尾酒（SPN _CT），它不仅可以将光能转换为热能，而且还可以在光激发停止后发出与温度相关的发光。由于消除了组织自发荧光，SPN _CT的这种余辉发光比荧光更灵敏地检测到肿瘤，而它的温度依赖性使肿瘤温度可以在近红外（NIR）激光照射下进行光学监测。因此，SPN _CT 代表了第一个能够在无需实时光激发的情况下实现光学成像引导PTT的有机光学纳米系统。