Palladium‐Catalyzed Cascade C−O Cleavage and C−H Alkenylation of Phosphinyl Allenes: An Expeditious Approach to 3‐Alkenyl Benzo[b]phosphole Oxides,Advanced Synthesis & Catalysis

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Palladium‐Catalyzed Cascade C−O Cleavage and C−H Alkenylation of Phosphinyl Allenes: An Expeditious Approach to 3‐Alkenyl Benzo[b]phosphole Oxides
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-03-25 , DOI: 10.1002/adsc.201800103
Teng Liu ₁ , Xue Sun ₁ , Lei Wu _{1,

2}

Affiliation

A phosphine oxide‐directed intramolecular cyclization of phosphinyl allenes is established for the first time. The palladium‐catalyzed intramolecular cyclization provides an unprecedented cascade C−O cleavage and direct C−H alkenylation toward novel 3‐alkenyl benzo[b]phosphole oxides, along with broad group tolerance and high regioselectivity. Control experiments and mechanistic studies explain the sequential performance of C(sp³)‐OAr cleavage and P=O directed C(sp²)‐H activation.

中文翻译：

钯催化级联膦酰基烯丙基的C O裂解和CH H烯基化：3-烯基苯并[b]磷氧化物的一种快速方法

首次建立了由氧化膦定向的次膦基烯丙二烯分子内环化反应。钯催化的分子内环化作用提供了前所未有的级联C-O裂解和将CH-H烯基化成新型3-烯基苯并[ b ]磷氧化物的方法，并具有宽基团耐受性和高区域选择性。对照实验和机理研究解释了C（sp ³）-OAr裂解和P = O定向C（sp ²）-H活化的顺序性能。

更新日期：2018-03-25

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