A novel high-tech composite biomimetic matrixes for a wide range of medical purposes were prepared. The structure of scaffolds was inspired by the architecture of native decellularized tissue: material consists of a sponge and fibrous components of different spatial geometry based on cellulose acetate with collagen or chitosan filler. The fibrous component was prepared by electrospinning, the sponge – freeze-drying technique. The influence of main technological parameters, such as freeze mode, polymer type and concentration, etc. on the fiber-sponge architecture and properties was examined. It was shown that scaffolds with different types of microstructure can be obtained employing this technique. The impregnation of chitosan or collagen filler in fiber matrix also significantly improves mechanical properties up to 40 MPa for strength and 600 MPa for Young's modulus.

制备了用于多种医学目的的新型高科技复合仿生基质。支架的结构受到天然脱细胞组织结构的启发：材料由海绵和具有胶原或壳聚糖填充剂的醋酸纤维素制成的具有不同空间几何形状的纤维成分组成。纤维成分是通过静电纺丝，海绵-冷冻干燥技术制备的。研究了主要技术参数，如冷冻模式，聚合物类型和浓度等对纤维海绵结构和性能的影响。结果表明，采用这种技术可以获得具有不同类型的微观结构的支架。