Sixteen disulfides derived from disulfiram (Antabuse™) were evaluated as antibacterial agents. Derivatives with hydrocarbon chains of seven and eight carbons in length exhibited antibacterial activity against Gram-positive Staphylococcus, Streptococcus, Enterococcus, Bacillus, and Listeria spp. A comparison of the cytotoxicity and microsomal stability with disulfiram further revealed that the eight carbon chain analog was of lower toxicity to human hepatocytes and has a longer metabolic half-life. In the final analysis, this investigation concluded that the S-octylthio derivative is a more effective growth inhibitor of Gram-positive bacteria than disulfiram and exhibits more favorable cytotoxic and metabolic parameters over disulfiram.

评估了来自双硫仑（Antabuse™）的十六种二硫化物作为抗菌剂。具有七个碳原子和八个碳原子的烃链的衍生物表现出对革兰氏阳性葡萄球菌，链球菌，肠球菌，芽孢杆菌和李斯特菌的抗菌活性。用双硫仑对细胞毒性和微粒体稳定性的比较进一步表明，八碳链类似物对人肝细胞的毒性较低，且代谢半衰期较长。说到底，这个调查的结论是，小号-辛基硫代衍生物比双硫仑是更有效的革兰氏阳性细菌生长抑制剂，并且比双硫仑表现出更有利的细胞毒性和代谢参数。