Immunotherapy: Tear down this wall

Immunotherapy: Tear down this wall, Published online: 09 March 2018; doi:10.1038/nrc.2018.22

Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients.

中文翻译：

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免疫疗法：推倒这堵墙

免疫疗法：推倒这堵墙

免疫疗法：拆除这堵墙，在线发布：2018年3月9日; doi：10.1038 / nrc.2018.22

转移性肿瘤的浸润边缘中TGFβ信号的激活可导致T细胞排斥和免疫检查点治疗反应降低。在无反应者中抑制TGFβ可能有助于改善这些患者的预后。