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Taylor Dispersion of Polydisperse Nanoclusters and Nanoparticles: Modeling, Simulation, and Analysis
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-03-08 00:00:00 , DOI: 10.1021/acs.analchem.7b04476 Sandor Balog 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-03-08 00:00:00 , DOI: 10.1021/acs.analchem.7b04476 Sandor Balog 1
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The dimensions of ultrasmall inorganic nanoparticles (US-NPs) is in the heart of the design of diagnostic and therapeutic efficacy; yet its accurate measurement is challenging for most experimental techniques. We show here how to design and analyze Taylor dispersion experiments to characterize the two most sought-after parameters describing size distributions: the number-averaged mean size and polydispersity index. To demonstrate the power of the method, we simulated and analyzed taylograms corresponding to gold US-NPs distributed normally. By using simulation and including experimental noise, we had the advantage that the true values describing size distribution were known exactly, and thus, we were able test the absolute accuracy of our analysis and its robustness against noise. Theory and computational experiments were found in very good agreement, providing a significant step in the analysis of ultrasmall inorganic nanoparticles and Taylor dispersion experiments.
中文翻译：
多分散纳米团簇和纳米颗粒的泰勒分散：建模，模拟和分析
超小型无机纳米颗粒（US-NPs）的尺寸是诊断和治疗功效设计的核心。然而，对于大多数实验技术而言，其准确的测量都具有挑战性。我们在这里展示了如何设计和分析泰勒分散实验，以表征描述尺寸分布的两个最抢手的参数：数均平均尺寸和多分散指数。为了证明该方法的功效，我们模拟并分析了与正态分布的金US-NPs相对应的笔迹图。通过使用模拟并包括实验噪声，我们的优势是可以准确知道描述尺寸分布的真实值，因此，我们可以测试分析的绝对准确性及其对噪声的鲁棒性。
更新日期：2018-03-08
中文翻译：
多分散纳米团簇和纳米颗粒的泰勒分散：建模，模拟和分析
超小型无机纳米颗粒（US-NPs）的尺寸是诊断和治疗功效设计的核心。然而，对于大多数实验技术而言，其准确的测量都具有挑战性。我们在这里展示了如何设计和分析泰勒分散实验，以表征描述尺寸分布的两个最抢手的参数：数均平均尺寸和多分散指数。为了证明该方法的功效，我们模拟并分析了与正态分布的金US-NPs相对应的笔迹图。通过使用模拟并包括实验噪声，我们的优势是可以准确知道描述尺寸分布的真实值，因此，我们可以测试分析的绝对准确性及其对噪声的鲁棒性。
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