Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture,Materials Horizons

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Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture
Materials Horizons ( IF 12.2 ) Pub Date : 2018-03-08 00:00:00 , DOI: 10.1039/c7mh00877e
A. I. Neto _{1,

2,

3,

4,

5} , P. A. Levkin _{6,

7,

8,

9} , J. F. Mano _{1,

2,

3,

4,

5}

Affiliation

Microarrays are a technological breakthrough for high-throughput screening of large numbers of assays. We review the evolution of microarray platforms for 3D cell culture to exhibit complex biological environments for tissue engineering, diagnostics and disease models. Patterned microarrays with extreme wettabilities were suggested as a versatile platform for high-throughput assays to generate 3D cell environments, as well as to characterize and analyze biomaterials' properties and cell–cell and cell–biomaterial interactions. Among the emerging HTS approaches, platforms with extreme wettabilities have the potential to revolutionize biomedical research, offering opportunities for drug screening on 3D cell based-systems with high reproducibility, versatility and spatial control.

中文翻译：

图案化的超疏水表面可处理和表征生物材料和3D细胞培养

微阵列是用于大量分析的高通量筛选的一项技术突破。我们回顾了用于3D细胞培养的微阵列平台的演变，以展示用于组织工程，诊断和疾病模型的复杂生物环境。建议将具有极高润湿性的图案化微阵列用作高通量测定的通用平台，以生成3D细胞环境，以及表征和分析生物材料的特性以及细胞与细胞以及细胞与生物材料之间的相互作用。在新兴的高温超导方法中，具有极高润湿性的平台具有革新生物医学研究的潜力，为在具有高重现性，多功能性和空间控制性的基于3D细胞的系统上进行药物筛选提供了机会。

更新日期：2018-03-08

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