Exposure to diesel exhaust (DE) from vehicles and industry is hazardous and affects proper function of organ systems. DE can interfere with normal physiology after acute and chronic exposure to particulate matter (PM). Exposure leads to potential systemic disease processes in the central nervous, visual, hematopoietic, respiratory, cardiovascular, and renal systems. In this review, we give an overview of the epidemiological evidence supporting the harmful effects of diesel exhaust, and the numerous animal studies conducted to investigate the specific pathophysiological mechanisms behind DE exposure. Additionally, this review includes a summary of studies that used biomarkers as an indication of biological plausibility, and also studies evaluating new technology diesel exhaust (NTDE) and its systemic effects. Lastly, this review includes new approaches to improving DE emissions, and emphasizes the importance of ongoing study in this field of environmental health.

接触车辆和工业产生的柴油废气 (DE) 是危险的，会影响器官系统的正常功能。急性和慢性接触颗粒物 (PM) 后，DE 会干扰正常生理机能。接触会导致中枢神经、视觉、造血、呼吸、心血管和肾脏系统潜在的全身性疾病过程。在这篇综述中，我们概述了支持柴油机尾气有害影响的流行病学证据，以及为调查 DE 暴露背后的具体病理生理机制而进行的大量动物研究。此外，本综述还总结了使用生物标志物作为生物学合理性指标的研究，以及评估新技术柴油机尾气 (NTDE) 及其系统影响的研究。最后，本次审查包括改善 DE 排放的新方法，并强调了在这一环境健康领域正在进行的研究的重要性。