Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor,Organic Process Research & Development

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Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-03-08 00:00:00 , DOI: 10.1021/acs.oprd.7b00392
Feng Zhou _{1,

2} , Boyu Zhang ₁ , Hongchen Liu _{1,

2} , Zhenghui Wen _{1,

2} , Kejun Wang _{1,

2} , Guangwen Chen ₁

Affiliation

N-Alkyl-2-pyrrolidones have been widely used in the petrochemical industry, the agricultural chemical industry, electronic materials, etc. The distinct advantages of using N-alkyl-2-pyrrolidones as solvents or reaction media make them particularly important. A continuous-flow microreactor was exploited for the preparation of N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP) in a highly controlled and safe manner; thus, its use improved the efficiency of the process. Various conditions (temperature, residence time, molar ratio of amine to γ-butyrolactone (GBL), GBL concentration, water content, and presence of H₃BO₃ catalyst) were investigated to improve the synthesis of NMP/NEP. A microreactor was employed for the conversion of GBL to NMP and NEP, and the yields reached 94.7% for NMP and 93.9% for NEP under the optimized conditions. Furthermore, a kinetic model based on the reaction mechanism was proposed to guide the design and optimization of the synthesis of NMP/NEP.

中文翻译：

在连续流微反应器中轻松制备N-烷基-2-吡咯烷酮

N-烷基-2-吡咯烷酮已广泛用于石油化学工业，农业化学工业，电子材料等。使用N-烷基-2-吡咯烷酮作为溶剂或反应介质的独特优势使得它们特别重要。开发了一种连续流微反应器，用于以高度可控和安全的方式制备N-甲基-2-吡咯烷酮（NMP）和N-乙基-2-吡咯烷酮（NEP）。因此，它的使用提高了过程的效率。各种条件（温度，停留时间，胺与γ-丁内酯的摩尔比（GBL），GBL浓度，水含量和H ₃ BO _3的存在）催化剂）进行了研究，以改善NMP / NEP的合成。使用微反应器将GBL转化为NMP和NEP，在优化条件下，NMP的收率达到94.7％，NEP的收率达到93.9％。此外，提出了基于反应机理的动力学模型，指导NMP / NEP合成的设计和优化。

更新日期：2018-03-08

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