Fuzhuan Brick Tea Polysaccharides Attenuate Metabolic Syndrome in High-Fat Diet Induced Mice in Association with Modulation in the Gut Microbiota,Journal of Agricultural and Food Chemistry

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Fuzhuan Brick Tea Polysaccharides Attenuate Metabolic Syndrome in High-Fat Diet Induced Mice in Association with Modulation in the Gut Microbiota
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-03-08 00:00:00 , DOI: 10.1021/acs.jafc.8b00296
Guijie Chen ₁ , Minhao Xie ₁ , Peng Wan ₁ , Dan Chen ₁ , Zhuqing Dai ₁ , Hong Ye ₁ , Bing Hu ₁ , Xiaoxiong Zeng ₁ , Zhonghua Liu _{2,

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Affiliation

An increasing amount of evidence suggests that the gut microbiota composition and structure contribute to the pathophysiology of metabolic syndrome (MS), which has been put forward as a new target in the treatment of diet-induced MS. In this work, we aimed to investigate effects of Fuzhuan brick tea polysaccharides (FBTPS) on MS and gut microbiota dysbiosis in high-fat diet (HFD) fed mice and to further investigate whether its attenuation of MS is related to the modulation of gut microbiota. The results showed that FBTPS intervention could significantly attenuate metabolic syndrome in HFD-induced mice. Based on results of sequencing, FBTPS treatment could increase the phylogenetic diversity of HFD-induced microbiota. FBTPS intervention could significantly restore the HFD-induced increases in relative abundances of Erysipelotrichaceae, Coriobacteriaceae, and Streptococcaceae. Spearman’s correlation analysis showed that 44 key OTUs were negatively or positively associated with MS. Our results suggested that FBTPS could serve as a novel candidate for prevention of MS in association with the modulation of gut microbiota.

中文翻译：

福砖砖茶多糖与肠道菌群的调节作用减弱高脂饮食诱导小鼠的代谢综合征。

越来越多的证据表明，肠道菌群的组成和结构有助于代谢综合征（MS）的病理生理，这已被提出作为饮食诱导MS的新靶标。在这项工作中，我们旨在研究福砖砖茶多糖（FBTPS）对高脂饮食（HFD）喂养小鼠的MS和肠道菌群失调的影响，并进一步研究其减毒是否与肠道菌群的调节有关。结果表明，FBTPS干预可以显着减轻HFD诱导的小鼠的代谢综合征。根据测序结果，FBTPS处理可以增加HFD诱导的菌群的系统发育多样性。FBTPS干预可显着恢复HFD诱导的丹参科植物相对丰度的增加，肠杆菌科和链球菌科。Spearman的相关性分析显示，有44个主要OTU与MS呈负相关或呈正相关。我们的研究结果表明，FBTPS可以作为与肠道菌群调节相关的预防MS的新型候选药物。

更新日期：2018-03-08

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