Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Current strategies to identify naive T cells should be adjusted to take this heterogeneity into account. Here, we provide an integrated, revised view of the naive T cell compartment and discuss its implications for healthy ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.

中文翻译：

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人类幼稚T细胞的全谱

长期以来，朴素的T细胞一直被认为是发育同步，相当均质且静止的细胞群，其大小取决于年龄，胸腺输出和先前的感染。然而，越来越多的证据表明，幼稚T细胞在表型，功能，动力学和分化状态方面是异质的。当前识别幼稚T细胞的策略应加以调整，以考虑到这种异质性。在这里，我们提供了幼稚T细胞区室的完整，修订视图，并讨论了其对造血干细胞移植后健康衰老，新生儿免疫和T细胞重构的影响。