Although photodynamic therapy (PDT) has served as an important strategy for treatment of various diseases, it still experiences many challenges, such as shallow penetration of light, high‐dose light irradiation, and low therapy efficiency in deep tissue. Here, a low‐dose X‐ray‐activated persistent luminescence nanoparticle (PLNP)‐mediated PDT nanoplatform for depth‐independent and repeatable cancer treatment has been reported. In order to improve therapeutic efficiency, this study first synthesizes W(VI)‐doped ZnGa₂O₄:Cr PLNPs with stronger persistent luminescence intensity and longer persistent luminescence time than traditional ZnGa₂O₄:Cr PLNPs. The proposed PLNPs can serve as a persistent excitation light source for PDT, even after X‐ray irradiation has been removed. Both in vitro and in vivo experiments demonstrate that low‐dose (0.18 Gy) X‐ray irradiation is sufficient to activate the PDT nanoplatform and causes significant inhibitory effect on tumor progression. Therefore, such PDT nanoplatform will provide a promising depth‐independent treatment mode for clinical cancer therapy in the future.

中文翻译：

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W（VI）掺杂的持久发光纳米粒子的低剂量X射线活化用于深层组织光动力疗法

尽管光动力疗法（PDT）已成为治疗各种疾病的重要策略，但它仍然面临许多挑战，例如光的浅穿透，高剂量的光照射以及对深部组织的低治疗效率。在此，已经报道了一种低剂量X射线激活的持久发光纳米粒子（PLNP）介导的PDT纳米平台，用于深度独立和可重复的癌症治疗。为了提高治疗效率，本研究首先合成了掺有W（VI）的ZnGa ₂ O ₄：Cr PLNP，其持久发光强度和持久发光时间均比传统ZnGa ₂ O ₄更长。：Cr PLNP。所提出的PLNP可以用作PDT的持久激发光源，即使在去除X射线照射之后也是如此。体外和体内实验均表明，低剂量（0.18 Gy）的X射线辐射足以激活PDT纳米平台，并对肿瘤进展产生明显的抑制作用。因此，这种PDT纳米平台将为将来的临床癌症治疗提供一种有希望的深度独立治疗模式。