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Mechanically strong dual responsive nanocomposite double network hydrogel for controlled drug release of asprin
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2018-03-08 , DOI: 10.1016/j.jmbbm.2018.03.002
Yang Chen , Guocheng Song , Junrong Yu , Yan Wang , Jing Zhu , Zuming Hu

Mechanically strong dual/multi-stimuli-responsive smart hydrogels have attracted extensive attention in recent years. A novel tough, mechanical strong and biocompatible dual pH- and temperature- responsive poly (N-isopropylacrylamide) /clay (laponite XLG)/carboxymethyl chitosan (CMCTs) /genipin nanocomposite double network hydrogel was synthesized through a facile, one-pot free radical polymerization initiated by the ultraviolet light, using clay and the natural molecular-genipin as the cross-linkers instead of toxic organic molecules. Crucial factors, the content of CMCTs, clay and genipin, for synthesizing the mechanical strong hydrogels were investigated. When the content of CMCTs, clay and genipin were 5 wt%, 33.3 wt% and 0.175 wt%, respectively (to the weight of N-isopropylacrylamide), these prepared hydrogels exhibited a high tensile strength of 137.9 kPa at the failure strain of 446.1%. Furthermore, the relationship between swelling and deswelling rate of the synthesized hydrogels and the above crucial factors were also studied. Besides, the synthesized hydrogels displayed a considerable controlled release property of asprin by tuning their inner crosslink density. Owing to this property, they may have great potential in the drug delivery systems.



中文翻译:

具有机械强度的双响应纳米复合双网络水凝胶,可控制阿斯匹林的药物释放

具有机械强度的双/多刺激响应型智能水凝胶近年来引起了广泛的关注。通过一种容易的,一锅的自由基合成了一种新颖的,具有机械强度的,具有生物相容性的,对pH和温度有响应的双重pH和温度响应的聚(N-异丙基丙烯酰胺)/粘土(锂皂石XLG)/羧甲基壳聚糖(CMCT)/ genipin纳米复合双网络水凝胶。紫外光引发的聚合反应,是使用粘土和天然分子-genipinin作为交联剂,而不是有毒的有机分子。研究了重要的因素,包括CMCTs,粘土和Genipin的含量,以合成机械强度高的水凝胶。当CMCT,粘土和京尼平的含量分别为5重量%,33.3重量%和0.175重量%(相对于N-异丙基丙烯酰胺的重量)时,这些制备的水凝胶在破坏应变为446.1%时显示出137.9 kPa的高拉伸强度。此外,还研究了合成水凝胶的溶胀率和溶胀率与上述关键因素之间的关系。此外,合成的水凝胶通过调节其内部交联密度而显示出相当大的阿斯匹林控释性能。由于这种特性,它们在药物输送系统中可能具有巨大的潜力。

更新日期:2018-03-08
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