Serum therapy fell out of favor 80 years ago, but antibodies against infectious diseases are now experiencing a renaissance. With the evolution of antibiotic-resistant bacteria, the emergence of new pathogens, and a growing population of immunocompromised individuals coupled with improvements in antibody manufacturing and biological efficacy, antibodies are an increasingly attractive therapeutic option. In this review, we highlight successful clinical strategies and discuss recent applications of advanced antibody engineering approaches to combat infectious diseases. Case studies include antibody mixtures to neutralize Staphylococcus aureus; bispecific antibodies promoting Pseudomonas aeruginosa clearance; antibody-antibiotic conjugates to eradicate S. aureus from protected intracellular niches; and novel anti-RSV antibodies with extended serum half-life. These new designs are powerful strategies for targeting infectious diseases due to their abilities to target multiple antigens and induce novel clearance mechanisms.

血清疗法在80年前就失宠了，但是针对传染病的抗体正在经历复兴。随着抗生素抗性细菌的进化，新病原体的出现以及免疫功能低下的人群的不断增长，以及抗体生产和生物学功效的提高，抗体已成为越来越有吸引力的治疗选择。在这篇综述中，我们重点介绍了成功的临床策略，并讨论了先进的抗体工程方法在对抗传染病中的最新应用。案例研究包括中和金黄色葡萄球菌的抗体混合物; 促进铜绿假单胞菌清除的双特异性抗体；抗体-抗生素结合物消除金黄色葡萄球菌受保护的细胞内壁ni；以及具有延长的血清半衰期的新型抗RSV抗体。这些新设计具有针对多种抗原并诱导新的清除机制的能力，因此是针对传染病的强大策略。