Abstract The preparation of the titanium dioxide hollow particles encapsulating L-ascorbic acid via sol-gel process using inkjet nozzle has been performed, and the sustained release and the effect protecting against degradation of L-ascorbic acid in the particles were investigated. The morphology of titanium dioxide particles was evaluated by scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS). The sustained release and the effect protecting against degradation of L-ascorbic acid were estimated by dialysis bag method in phosphate buffer saline (PBS) (pH = 7.4) as release media. The prepared titanium dioxide particles exhibited spherical porous structures. The particle size distribution of the titanium dioxide particles was uniform. The hollow titanium dioxide particles encapsulating L-ascorbic acid showed the sustained release. It was also found that the degradation of L-ascorbic acid could be inhibited by encapsulating L-ascorbic acid in the titanium dioxide hollow particles.

中文翻译：

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L-抗坏血酸包封二氧化钛空心颗粒的制备及缓释

摘要 采用喷墨喷嘴通过溶胶-凝胶法制备了包裹L-抗坏血酸的二氧化钛空心颗粒，研究了颗粒中L-抗坏血酸的缓释和抗降解作用。通过扫描电子显微镜 (SEM) 和能量色散 X 射线光谱法 (EDS) 评估二氧化钛颗粒的形貌。在磷酸盐缓冲盐水 (PBS) (pH = 7.4) 作为释放介质中，通过透析袋法评估持续释放和防止 L-抗坏血酸降解的效果。制备的二氧化钛颗粒呈现球形多孔结构。二氧化钛颗粒的粒度分布均匀。包裹 L-抗坏血酸的中空二氧化钛颗粒显示出持续释放。还发现将L-抗坏血酸包裹在二氧化钛中空颗粒中可以抑制L-抗坏血酸的降解。