Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.

中文翻译：

---

吡唑甲星A和B：产气单胞菌Lechevalieria aerocolonigenes K10-0216的新噻唑基吡啶的结构和生物活性。

通过硅胶和HPLC纯化从稀有的放线菌菌株好氧致病性假单胞菌K10-0216的培养液中分离出两种新的抗生素，分别命名为吡唑米星A和B。通过核磁共振和质谱法阐明了吡唑米星A和B的化学结构为新的噻唑基吡啶化合物。吡唑啉星A和B均显示出抗菌活性。