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Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2018-Jun-01 , DOI: 10.1038/s41429-018-0038-y
Tōru Kimura , Yuki Inahashi , Hirotaka Matsuo , Takuya Suga , Masato Iwatsuki , Kazuro Shiomi , Yōko Takahashi , Satoshi Ōmura , Takuji Nakashima

Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.

中文翻译:

吡唑甲星A和B:产气单胞菌Lechevalieria aerocolonigenes K10-0216的新噻唑基吡啶的结构和生物活性。

通过硅胶和HPLC纯化从稀有的放线菌菌株好氧致病性假单胞菌K10-0216的培养液中分离出两种新的抗生素,分别命名为吡唑米星A和B。通过核磁共振和质谱法阐明了吡唑米星A和B的化学结构为新的噻唑基吡啶化合物。吡唑啉星A和B均显示出抗菌活性。
更新日期:2018-03-07
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