Formation and stabilization of pores in bilayer membranes by peptide-like amphiphilic polymers,Soft Matter

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Formation and stabilization of pores in bilayer membranes by peptide-like amphiphilic polymers
Soft Matter ( IF 2.9 ) Pub Date : 2018-03-07 00:00:00 , DOI: 10.1039/c7sm02404e
Ankush Checkervarty _{1,

2,

3,

3,

4} , Marco Werner _{1,

2,

3,

5,

6} , Jens-Uwe Sommer _{1,

2,

3,

3,

4}

Affiliation

We study pore formation in models of lipid bilayer membranes interacting with amphiphilic copolymers mimicking anti-microbial peptides using Monte Carlo simulations and we rationalize our results by a simple brush-model for the fluid membrane. In our study a weak tension on the membrane is required to observe pore-formation induced by the adsorption of flexible amphiphilic copolymers. The copolymers enhance the pore stability by decreasing the line tension due to weak adsorption along the rim of the pore. Pore formation is enhanced with increasing length of copolymers or stronger stretching of the membrane. Both solvent and copolymer permeability increase as the pore becomes stable. Pore-formation proceeds via a meta-stable pore-state according to a discontinuous phase transition scenario which lead to finite pore-sizes at once. Our generic model of copolymer-induced pore-formation does not require high polymer concentration at the pores nor any self-organization of the copolymers to open the pore.

中文翻译：

肽样两亲性聚合物在双层膜中形成和稳定孔

我们使用蒙特卡罗模拟研究脂质双层膜与模拟抗菌肽的两亲共聚物相互作用的脂质双层膜模型中的孔形成，并通过简单的刷膜流体模型使我们的结果合理化。在我们的研究中，需要通过在膜上施加弱张力来观察由柔性两亲共聚物吸附引起的孔形成。该共聚物通过降低由于沿孔的边缘的弱吸附而引起的线张力来增强孔的稳定性。孔的形成随着共聚物长度的增加或膜的更强拉伸而增强。随着孔变得稳定，溶剂和共聚物的渗透性均增加。孔形成通过根据不连续的相变情况，亚稳态的孔隙状态会立即导致有限的孔径。我们的共聚物诱导的孔形成的通用模型不需要孔中的高聚合物浓度，也不需要共聚物的任何自组织来打开孔。

更新日期：2018-03-07

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