Synthesis ( IF 2.2 ) Pub Date : 2018-03-07 , DOI: 10.1055/s-0036-1591773 Krisztina Kónya 1 , Zoltán Sipos 1
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Dedicated to the memory of Prof. Tamás Patonay
Abstract
A microwave-assisted intramolecular direct arylation method for the synthesis of benzopyran-fused flavone derivatives containing natural flavone backbones is described. Different polyalkoxy flavones were synthesized and functionalized with 2-bromobenzyl bromide. The resulting compounds were subjected to palladium-catalyzed intramolecular direct arylation reactions supported by microwave irradiation to produce fused tetracyclic flavones. In the case of the 7-substituted chrysin derivative, the regioselectivity of the coupling was also examined.
A microwave-assisted intramolecular direct arylation method for the synthesis of benzopyran-fused flavone derivatives containing natural flavone backbones is described. Different polyalkoxy flavones were synthesized and functionalized with 2-bromobenzyl bromide. The resulting compounds were subjected to palladium-catalyzed intramolecular direct arylation reactions supported by microwave irradiation to produce fused tetracyclic flavones. In the case of the 7-substituted chrysin derivative, the regioselectivity of the coupling was also examined.
中文翻译：
微波辅助分子内C–H活化合成苯并吡喃融合的黄酮衍生物
献给TamásPatonay教授的纪念
抽象的
描述了一种微波辅助的分子内直接芳基化方法，用于合成含有天然黄酮骨架的苯并吡喃稠合的黄酮衍生物。合成了不同的聚烷氧基黄酮，并用2-溴苄基溴官能化。使得到的化合物经受由微波辐射支持的钯催化的分子内直接芳基化反应，以产生稠合的四环黄酮。在7-取代的菊花链衍生物的情况下，还检查了偶联的区域选择性。
描述了一种微波辅助的分子内直接芳基化方法，用于合成含有天然黄酮骨架的苯并吡喃稠合的黄酮衍生物。合成了不同的聚烷氧基黄酮，并用2-溴苄基溴官能化。使得到的化合物经受由微波辐射支持的钯催化的分子内直接芳基化反应，以产生稠合的四环黄酮。在7-取代的菊花链衍生物的情况下，还检查了偶联的区域选择性。
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