HBED-CC is a bifunctional complexing agent that, at ambient temperature, tightly chelates the trivalent radiometal 68 Ga (T 1/2 = 68 min). This complexing agent has attracted a lot of interest in tumor imaging applications. Depending on the chemical structure, different HBED-CC variants may be employed as radiolabeling precursor for the synthesis of desired radiopharmaceuticals. In this context, HBED-CC-tris(tert-butyl ester) is the only known monovalent variant of HBED-CC which is used for the synthesis of non-symmetric HBED-CC-based radiopharmaceuticals. Commercial HBED-CC-tris( tert -butyl ester) is very ­expensive, with limited availability. Nevertheless, no synthetic procedure for this useful product has been reported to date. This work introduces a convenient and comparatively cost-efficient method for the preparation of HBED-CC-tris( tert -butyl ester).

中文翻译：

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HBED-CC-三（叔丁酯）的简便合成

HBED-CC 是一种双功能络合剂，可在环境温度下紧密螯合三价放射性金属 68 Ga（T 1/2 = 68 分钟）。这种络合剂引起了肿瘤成像应用的广泛兴趣。根据化学结构，不同的 HBED-CC 变体可用作合成所需放射性药物的放射性标记前体。在这种情况下，HBED-CC-三（叔丁酯）是 HBED-CC 唯一已知的单价变体，用于合成基于非对称 HBED-CC 的放射性药物。商用 HBED-CC-tris（叔丁酯）非常昂贵，供应有限。尽管如此，迄今为止还没有报道过这种有用产品的合成程序。