Bromotrifluoromethane: A Useful Reagent for Hydrotrifluoromethylation of Alkenes and Alkynes,Synlett

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Bromotrifluoromethane: A Useful Reagent for Hydrotrifluoromethylation of Alkenes and Alkynes
Synlett ( IF 1.7 ) Pub Date : 2018-03-07 , DOI: 10.1055/s-0036-1591944
Xing Zheng ₁ , Xingang Zhang ₂ , Yu-Yan Ren ₁

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Bromotrifluoromethane (CF3Br) is a simple, inexpensive and abundant industrial material employed as a trifluoromethylating reagent. However, only limited strategies using CF3Br as a fluorine source are reported. Herein, we describe a visible-light-induced hydrotrifluoromethylation of alkenes and alkynes with CF3Br. The reaction proceeds under mild conditions with good functional group tolerance, providing a new route for the application of BrCF3 in organic synthesis.

中文翻译：

溴三氟甲烷：一种用于烯烃和炔烃氢三氟甲基化的有用试剂

溴三氟甲烷 (CF3Br) 是一种简单、廉价且丰富的工业材料，用作三氟甲基化试剂。然而，仅报道了使用 CF3Br 作为氟源的有限策略。在此，我们描述了烯烃和炔烃与 CF3Br 的可见光诱导的氢三氟甲基化。该反应在温和的条件下进行，具有良好的官能团耐受性，为BrCF3在有机合成中的应用提供了新的途径。

更新日期：2018-03-07

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