Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives†,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-03-08 00:00:00 , DOI: 10.1039/c8qo00125a
Ben Niu _{1,

2,

3,

4,

5} , Ruixing Liu _{6,

7,

8,

9,

10} , Yin Wei _{6,

7,

8,

9,

10} , Min Shi _{1,

2,

3,

4,

5}

Affiliation

A facile synthetic method to access 4-amino-isoquinolin-1(2H)-one and oxazole derivatives was disclosed in this paper. The reaction of N-(pivaloyloxy)-amides with ynamides produced 4-amino-isoquinolin-1(2H)-ones in good yields in the presence of Cp*Rh(III) catalyst through a C–H bond functionalization. Using Sc(OTf)₃ as the catalyst, oxazole derivatives were obtained in good yields from the same reaction. This protocol features good functional group tolerance and excellent regioselectivity.

中文翻译：

催化剂控制的4-氨基-异喹啉-1（2 H）-one和恶唑衍生物的合成†

本文公开了一种简便的合成方法，用于获得4-氨基-异喹啉-1（2 H）-one和恶唑衍生物。在Cp * Rh（III）催化剂存在下，通过C–H键官能化，N-（新戊酰氧基）-酰胺与乙酰胺的反应以高收率产生了4-氨基-异喹啉-1（2 H）- 。使用Sc（OTf）₃作为催化剂，可以从同一反应中以高收率获得恶唑衍生物。该方案具有良好的功能基团耐受性和出色的区域选择性。

更新日期：2018-03-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11