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Biosensor Array of Interpenetrating Polymer Network with Photonic Film Templated from Reactive Cholesteric Liquid Crystal and Enzyme‐Immobilized Hydrogel Polymer
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-03-07 , DOI: 10.1002/adfm.201707562
Kyung-Gyu Noh 1 , Soo-Young Park 1
Affiliation  

A biosensor array is fabricated using an interpenetrating polymer network consisting of photonic film templated from reactive cholesteric liquid crystal (CLC) and enzyme‐immobilized polyacrylic acid (PAA). The solid‐state photonic film on the glass substrate is successfully templated by ultraviolet (UV) curing of the reactive CLC mixture of a reactive mesogen mixture of RMM 727 (from Merck) and a nonreactive chiral dopant of (S)‐4‐cyano‐4′‐(2‐methylbutyl)biphenyl following the extraction of the chiral dopant. The acrylic acid monomer mixed with a cross‐linker of tri(propylene glycol) diacrylate is infiltrated into the extracted space of the photonic film, and UV‐cured with a photomask to obtain a patterned array‐dot film. The interpenetrated cholesteric liquid crystal/hydrogel polymer network (CLC‐hydrogel‐IPN) array is further functionalized in the individual dots with urease, for a model study of biosensor array applications. The dots of the CLC‐hydrogel‐IPN array respond independently to the urea by a color change with high sensitivity and stability. Thus, the patterned CLC‐hydrogel‐IPN can be used as a new biosensor array for cost‐effective and easy visual detection without any sophisticated instruments.

中文翻译:

具有反应性胆甾型液晶和酶固定水凝胶聚合物的光子膜为模板的互穿聚合物网络的生物传感器阵列

生物传感器阵列是使用互穿聚合物网络制造的,该网络由以反应性胆甾型液晶(CLC)和酶固定化聚丙烯酸(PAA)为模板的光子膜组成。通过紫外线(UV)固化RMM 727(来自默克公司)的反应性液晶元混合物和(S的非反应性手性掺杂剂)的反应性CLC混合物,成功地将玻璃基板上的固态光子膜模板化。)-手性掺杂剂提取后的4-氰基-4'-(2-甲基丁基)联苯。将丙烯酸单体与三丙烯酸丙二醇酯的交联剂混合,渗入光子膜的提取空间中,并用光掩模进行紫外线固化,以获得带图案的阵列点膜。相互渗透的胆甾型液晶/水凝胶聚合物网络(CLC-水凝胶-IPN)阵列在尿素酶的各个点中进一步功能化,用于生物传感器阵列应用的模型研究。CLC-水凝胶-IPN阵列的点通过颜色变化独立地响应尿素,具有高灵敏度和稳定性。因此,图案化的CLC-水凝胶-IPN可以用作新型生物传感器阵列,而无需任何复杂的仪器即可进行经济高效的视觉检测。
更新日期:2018-03-07
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