Background

Zika virus (ZIKV), was widely reported in Latin America and has been associated with neuropathologies, as microcephaly, but only few seroprevalence studies have been published to date. Our objective was to determine the seroprevalence amongst Bolivian blood donors and estimate the future potential circulation of the virus.

Methodology

A ZIKV seroprevalence study was conducted between December 2016 and April 2017 in 814 asymptomatic Bolivian volunteer blood donors residing in various eco-environments corresponding to contrasting entomological activities. It was based on detection of IgG to ZIKV using NS1 ELISA screening, followed by a seroneutralisation test in case of positive or equivocal ELISA result.

Conclusions/Significance

Analysis revealed that ZIKV circulation occurred in tropical areas (Beni: 39%; Santa Cruz de la Sierra: 21.5%) but not in highlands (~0% in Cochabamba, La Paz, Tarija). It was modulated by Aedes aegypti activity and the virus spread was not limited by previous immunity to dengue. Cases were geo-localised in a wide range of urban areas in Santa Cruz and Trinidad. No differences in seroprevalence related to gender or age-groups could be identified. It is concluded that ZIKV has been intensely circulating in the Beni region and has still a significant potential for propagating in the area of Santa Cruz.

中文翻译：

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玻利维亚的寨卡病毒流行病学：自愿献血者的血清阳性率研究

背景

寨卡病毒（ZIKV）在拉丁美洲得到广泛报道，并与神经病理学有关，如小头畸形，但迄今为止，仅有很少的血清流行性研究发表。我们的目标是确定玻利维亚献血者中的血清阳性率，并估计病毒的未来潜在传播。

方法

在2016年12月至2017年4月之间，对814种无症状的玻利维亚自愿献血者进行了ZIKV血清阳性率研究，这些献血者生活在与昆虫活动相反的各种生态环境中。它基于使用NS1 ELISA筛选检测到ZIKV的IgG，然后在ELISA结果呈阳性或含糊不清的情况下进行血清ututalization测试。

结论/意义

分析显示，ZIKV循环发生在热带地区（贝尼：39％；圣克鲁斯－德拉塞拉：21.5％），但没有发生在高地（科恰班巴，拉巴斯，塔里哈约0％）。它受到埃及伊蚊活性的调节，病毒的传播不受先前对登革热的免疫力的限制。案件在圣克鲁斯和特立尼达的大范围城市地区进行了地理定位。没有发现与性别或年龄组相关的血清阳性率差异。结论是，ZIKV在贝尼地区一直活跃，在圣克鲁斯地区仍具有巨大的传播潜力。