PLOS Neglected Tropical Diseases ( IF 3.4 ) Pub Date : 2018-03-07 , DOI: 10.1371/journal.pntd.0006239 Paola Mariela Saba Villarroel 1, 2 , Elif Nurtop 1 , Boris Pastorino 1 , Yelin Roca 2 , Jan Felix Drexler 3, 4 , Pierre Gallian 5 , Thomas Jaenisch 6 , Isabelle Leparc-Goffart 7 , Stéphane Priet 1 , Laetitia Ninove 1 , Xavier de Lamballerie 1
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Background
Zika virus (ZIKV), was widely reported in Latin America and has been associated with neuropathologies, as microcephaly, but only few seroprevalence studies have been published to date. Our objective was to determine the seroprevalence amongst Bolivian blood donors and estimate the future potential circulation of the virus.
Methodology
A ZIKV seroprevalence study was conducted between December 2016 and April 2017 in 814 asymptomatic Bolivian volunteer blood donors residing in various eco-environments corresponding to contrasting entomological activities. It was based on detection of IgG to ZIKV using NS1 ELISA screening, followed by a seroneutralisation test in case of positive or equivocal ELISA result.
Conclusions/Significance
Analysis revealed that ZIKV circulation occurred in tropical areas (Beni: 39%; Santa Cruz de la Sierra: 21.5%) but not in highlands (~0% in Cochabamba, La Paz, Tarija). It was modulated by Aedes aegypti activity and the virus spread was not limited by previous immunity to dengue. Cases were geo-localised in a wide range of urban areas in Santa Cruz and Trinidad. No differences in seroprevalence related to gender or age-groups could be identified. It is concluded that ZIKV has been intensely circulating in the Beni region and has still a significant potential for propagating in the area of Santa Cruz.
中文翻译：
玻利维亚的寨卡病毒流行病学：志愿者献血者的血清阳性率研究
背景
寨卡病毒 (ZIKV) 在拉丁美洲被广泛报道，并与小头畸形等神经病理学相关，但迄今为止仅发表了很少的血清流行率研究。我们的目标是确定玻利维亚献血者的血清流行率并估计病毒未来的潜在传播。
方法
2016 年 12 月至 2017 年 4 月期间，对居住在与不同昆虫学活动相对应的各种生态环境中的 814 名无症状玻利维亚志愿献血者进行了一项 ZIKV 血清流行率研究。它基于使用 NS1 ELISA 筛选检测 ZIKV IgG，然后在 ELISA 结果呈阳性或模棱两可的情况下进行血清中和测试。
结论/意义
分析显示，ZIKV 循环发生在热带地区（贝尼：39%；圣克鲁斯德拉谢拉：21.5%），但不在高地（科恰班巴、拉巴斯、塔里哈约为 0%）。它受到埃及伊蚊活动的调节，病毒传播不受先前对登革热免疫的限制。病例分布在圣克鲁斯和特立尼达的多个城市地区。无法确定与性别或年龄组相关的血清阳性率存在差异。结论是，ZIKV在贝尼地区正在强烈传播，并且在圣克鲁斯地区仍有巨大的传播潜力。
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