“Smart” bioresponsive materials, which are sensitive to biological signals or pathological abnormalities, are appealing therapeutic platforms for the development of next-generation cancer theranostics. In this work, a novel “stepwise extraction” strategy has been proposed and demonstrated in constructing injectable bioresponsive composite implant, which features unique theranostic responsivenesses to exogenous and external triggers. The as-designed implant exhibits theranostic functions and biodegradability for cancer treatment based on the change of intratumoral microenvironment and the needs of therapeutic process. This “stepwise extraction” process, that is, “solvent extraction”, “manganese extraction” and “phosphorus extraction”, significantly promoted the biodegradation and disintegration of the bioresponsive implant step by step, accompanied by the corresponding component releases from the PLGA framework and furthermore, accomplished different specific theranostic functions needed at different treatment stages. This is the first demonstration of bioresponsive organic-inorganic hybrid implant with marked theranostic functions and excellent biodegradability by a “stepwise extraction” approach, paving the way to the solutions of unsatisfactory therapeutic efficacy and strong side effects in current cancer therapeutic modalities.

对生物信号或病理异常敏感的“智能”生物响应材料正在吸引下一代癌症治疗学发展的治疗平台。在这项工作中，提出了一种新颖的“逐步提取”策略，并在构建可注射的生物反应性复合材料植入物时得到了证明，该方法具有对外源和外部触发的独特的治疗反应性。根据肿瘤内微环境的变化和治疗过程的需要，设计好的植入物具有治疗癌症的功能和可生物降解性。这种“逐步萃取”过程，即“溶剂萃取”，“锰萃取”和“磷萃取”，逐步促进了生物响应性植入物的生物降解和分解，伴随着PLGA框架中相应成分的释放，此外，还完成了不同治疗阶段所需的不同特定治疗方法功能。这是生物反应性有机-无机杂化植入物的首个演示，它通过“逐步提取”方法具有显着的治疗功效和出色的生物降解性，为当前癌症治疗方式中疗效不理想和副作用严重的解决方案铺平了道路。