Owing to their favorable molecular topology, atropisomers represent particularly valuable chiral scaffolds for numerous applications throughout academic research and industry. Nevertheless, whereas various well-established catalyst-controlled methodologies allow addressing stereocenter configuration, efficient procedures to prepare axially chiral compounds in high isomeric purity are still scarce. Complementary to the comprehensive reviews in the area, this Perspective features representative advances for the catalyst-stereocontrolled synthesis of atropisomeric scaffolds. With a focus on axially chiral motifs frequently utilized in catalysis or medicinal chemistry, selected recent examples encompassing unique stereoselective transition metal, hydrogen bond, ion pairing, chiral phosphoric acid, and amine catalysis are highlighted.

中文翻译：

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催化剂控制的立体异构合成的阻转异构体

由于其有利的分子拓扑结构，阻转异构体代表了在整个学术研究和工业中的众多应用中特别有价值的手性支架。然而，尽管各种公认的催化剂控制方法允许解决立体中心构型，但仍缺乏制备高异构体纯度的轴向手性化合物的有效方法。与该地区的全面综述相辅相成，本《观点》以代表性的进展为代表，对阻转异构体骨架进行了催化剂立体控制的合成。着重于在催化或药物化学中经常使用的轴向手性基序，突出了最近的一些实例，包括独特的立体选择性过渡金属，氢键，离子对，手性磷酸和胺催化。