Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits.

中文翻译：

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TREM2和Amyloid Beta：爱恨交加的关系。

TREM2突变会增加晚期AD的风险。在本期《神经元》中，Zhao等人。（2018）显示TREM2与Aβ结合以增强其清除率，Lee等（2006）。（2018）证明人TREM2在AD小鼠中的表达改善了Aβ相关的缺陷。