Structure, Content, and Bioactivity of Food-Derived Peptides in the Body,Journal of Agricultural and Food Chemistry

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Structure, Content, and Bioactivity of Food-Derived Peptides in the Body
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acs.jafc.8b00390
Kenji Sato ₁

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Orally administered peptides are assumed to be degraded into amino acids in the body. However, our recent studies revealed some food-derived prolyl and pyroglutamyl peptides with 2–3 amino acid residues in the blood of humans and animals, while most of the peptides in the endoproteinase digest of food protein are degraded by exopeptidase. Some food-derived dipeptides in the body display in vitro and in vivo biological activities. These facts indicate that the biological activities of food-derived peptides in the body rather than those in food are crucial to understanding the mechanism of the beneficial effects of orally administered peptides.

中文翻译：

体内食物衍生肽的结构，含量和生物活性

口服肽被认为会在体内降解为氨基酸。但是，我们最近的研究发现，在人和动物的血液中，某些食物来源的脯氨酰和焦谷氨酰胺肽具有2-3个氨基酸残基，而食物蛋白内切蛋白酶消化物中的大多数肽都被外肽酶降解。体内某些食物衍生的二肽具有体外和体内生物活性。这些事实表明，食物中的肽在体内而不是食物中的生物活性对于理解口服肽的有益作用机理至关重要。

更新日期：2018-03-06

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