The health of an organism is intimately linked to its ability to repair damaged DNA. Importantly, DNA repair processes are highly dynamic. This highlights the necessity of characterizing DNA repair in live cells. Advanced genome editing and imaging approaches allow us to visualize damaged DNA and its associated factors in real time. Here, we summarize both established and recent methods that are used to induce DNA damage and visualize damaged DNA and its repair in live cells.

中文翻译：

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观看现场表演：在体内可视化受损的 DNA

生物体的健康与其修复受损 DNA 的能力密切相关。重要的是，DNA 修复过程是高度动态的。这突出了在活细胞中表征 DNA 修复的必要性。先进的基因组编辑和成像方法使我们能够实时可视化受损的 DNA 及其相关因素。在这里，我们总结了用于诱导 DNA 损伤和可视化受损 DNA 及其在活细胞中修复的既定方法和最新方法。