当前位置：
X-MOL 学术
›
Adv. Healthcare Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Conceptually Novel Black Phosphorus/Cellulose Hydrogels as Promising Photothermal Agents for Effective Cancer Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-06 , DOI: 10.1002/adhm.201701510 Chenyang Xing 1 , Shiyou Chen 1 , Meng Qiu 1 , Xin Liang 1, 2 , Quan Liu 3, 4 , Qingshuang Zou 1 , Zhongjun Li 1 , Zhongjian Xie 1 , Dou Wang 3, 4 , Biqin Dong 5 , Liping Liu 3 , Dianyuan Fan 1 , Han Zhang 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-06 , DOI: 10.1002/adhm.201701510 Chenyang Xing 1 , Shiyou Chen 1 , Meng Qiu 1 , Xin Liang 1, 2 , Quan Liu 3, 4 , Qingshuang Zou 1 , Zhongjun Li 1 , Zhongjian Xie 1 , Dou Wang 3, 4 , Biqin Dong 5 , Liping Liu 3 , Dianyuan Fan 1 , Han Zhang 1
Affiliation
|
Black phosphorus (BP) has recently emerged as an intriguing photothermal agent in photothermal therapy (PTT) against cancer by virtue of its high photothermal efficiency, biocompatibility, and biodegradability. However, naked BP is intrinsically characterized by easy oxidation (or natural degradation) and sedimentation inside the tumor microenvironment, leading to a short‐term therapeutic and inhomogeneous photothermal effect. Development of BP‐based nanocomposites for PTT against cancer therefore remains challenging. The present work demonstrates that green and injectable composite hydrogels based on cellulose and BP nanosheets (BPNSs) are of great efficiency for PTT against cancer. The resultant cellulose/BPNS‐based hydrogel possesses 3D networks with irregular micrometer‐sized pores and thin, strong cellulose‐formed walls and exhibits an excellent photothermal response, enhanced stability, and good flexibility. Importantly, this hydrogel nanoplatform is totally harmless and biocompatible both in vivo and in vitro. This work may facilitate the development of BP–polymer‐based photothermal agents in the form of hydrogels for biomedical‐related clinic applications.
中文翻译：
从概念上讲，新颖的黑磷/纤维素水凝胶可作为有效的癌症治疗用光热剂。
黑磷（BP）由于其高的光热效率，生物相容性和可生物降解性，最近在抗癌光热疗法（PTT）中成为一种引人入胜的光热剂。但是，裸露的BP本质上具有肿瘤微环境内部易于氧化（或自然降解）和沉淀的特征，从而导致短期治疗和不均匀的光热效应。因此，开发用于抗癌PTT的基于BP的纳米复合材料仍然具有挑战性。本工作表明，基于纤维素和BP纳米片（BPNSs）的绿色可注射复合水凝胶对于PTT抗癌具有很高的功效。所得的基于纤维素/ BPNS的水凝胶具有3D网络，该网络具有不规则的微米级孔和薄的，坚固的纤维素壁，并具有出色的光热响应，增强的稳定性和良好的柔韧性。重要的是，这种水凝胶纳米平台在体内和体外完全无害且具有生物相容性。这项工作可能有助于开发基于BP聚合物的水凝胶形式的光热剂，用于生物医学相关的临床应用。
更新日期：2018-03-06
中文翻译：
从概念上讲，新颖的黑磷/纤维素水凝胶可作为有效的癌症治疗用光热剂。
黑磷（BP）由于其高的光热效率，生物相容性和可生物降解性，最近在抗癌光热疗法（PTT）中成为一种引人入胜的光热剂。但是，裸露的BP本质上具有肿瘤微环境内部易于氧化（或自然降解）和沉淀的特征，从而导致短期治疗和不均匀的光热效应。因此，开发用于抗癌PTT的基于BP的纳米复合材料仍然具有挑战性。本工作表明，基于纤维素和BP纳米片（BPNSs）的绿色可注射复合水凝胶对于PTT抗癌具有很高的功效。所得的基于纤维素/ BPNS的水凝胶具有3D网络，该网络具有不规则的微米级孔和薄的，坚固的纤维素壁，并具有出色的光热响应，增强的稳定性和良好的柔韧性。重要的是，这种水凝胶纳米平台在体内和体外完全无害且具有生物相容性。这项工作可能有助于开发基于BP聚合物的水凝胶形式的光热剂，用于生物医学相关的临床应用。
京公网安备 11010802027423号