Abstract A wide range of 4-chloro-3,4-dihydroquinazolines hybrid isoniazid derivatives were synthesised efficiently via reaction of 4-chloro-3,4-dihydroquinazolines with isoniazid in the presence of catalytic amount of N,N-diisopropylethylamine (DIPEA) under refluxing methanol. All the title molecules were characterized by 13C NMR, 1H NMR, Mass and IR spectroscopy. All the compounds were tested for anti-malarial, anti-microbial and anti-tuberculosis activities. They were further tested for the cytotoxic feature. In-silico molecular docking study and ADME properties were also studied for the title molecules.

中文翻译：

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N'-(Quinazolin-4-yl)异烟酰肼的合成及其生物筛选、对接和ADME研究

摘要 在催化量的 N,N-二异丙基乙胺 (DIPEA) 存在下，4-氯-3,4-二氢喹唑啉与异烟肼反应，高效合成了多种 4-氯-3,4-二氢喹唑啉杂化异烟肼衍生物。回流甲醇。所有标题分子均通过 13C NMR、1H NMR、质谱和红外光谱进行表征。测试了所有化合物的抗疟疾、抗微生物和抗结核活性。进一步测试了它们的细胞毒性特征。还研究了标题分子的计算机内分子对接研究和 ADME 特性。