General control of amino acid synthesis 5 (GCN5) like-1 (GCN5L1) was identified as a novel gene with sequence homology to the histone acetyltransferase Gcn5. Subsequent protein-interaction studies identified GCN5L1 as a subunit of the multiprotein lysosome biogenesis complex, resulting in an alternative designation as biogenesis of lysosome-related organelle complex 1 subunit 1 (BLOS1 or BLOC1S1). Despite the distinct nomenclatures, GCN5L1/BLOS1 has been shown to play crucial roles in mitochondria, endosomes, lysosomes, and synaptic vesicle precursors (SVPs). GCN5L1/BLOS1 controls mitochondrial protein acetylation, modulates metabolic pathways, and orchestrates retrograde mitochondria-to-nucleus signaling. It also contributes to endosome-lysosome and vesicle trafficking and to endolysosomal function. Here we discuss the intracellular roles of GCN5L1/BLOS1 in the hope of linking mitochondria-centric effects to cytosolic vesicle biology.

中文翻译：

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GCN5L1/BLOS1 连接乙酰化、细胞器重塑和代谢。


氨基酸合成通用控制 5 (GCN5) like-1 (GCN5L1) 被鉴定为与组蛋白乙酰转移酶 Gcn5 具有序列同源性的新基因。随后的蛋白质相互作用研究将 GCN5L1 确定为多蛋白溶酶体生物发生复合物的一个亚基，从而产生了另一种名称：溶酶体相关细胞器复合物 1 亚基 1（BLOS1 或 BLOC1S1）的生物发生。尽管命名不同，但 GCN5L1/BLOS1 已被证明在线粒体、内体、溶酶体和突触小泡前体 (SVP) 中发挥着至关重要的作用。 GCN5L1/BLOS1 控制线粒体蛋白乙酰化、调节代谢途径并协调逆行线粒体到细胞核的信号传导。它还有助于内体-溶酶体和囊泡运输以及内溶酶体功能。在这里，我们讨论 GCN5L1/BLOS1 的细胞内作用，希望将线粒体中心效应与胞质囊泡生物学联系起来。